Do the eyes have it? New approach to diagnosing mental illness

Dan Schulman

ACCORDING TO A POPULAR, IF CLICHED, adage, the eyes are the window to the soul. Researchers at the University of Illinois at Chicago believe the eyes may also help diagnose mental disorders such as schizophrenia, depression and autism.

Researchers have long reported irregularities in the eye movements of patients with mental disorders. Patients with autism have difficulty maintaining eye contact with others. Schizophrenics are often unable to keep their eyes focused on slow-moving objects. These abnormalities, researchers say, reflect defects in the neural circuitry of the brain–defects that are well documented but as yet poorly understood.

With a renewed $1.2 million grant from the National Institute of Mental Health, which has funded their work since 1988, John Sweeney, director of the Center for Cognitive Medicine in UIC’s department of psychiatry, and his colleagues are spearheading a research initiative to study and catalog eye movement patterns in patients with psychiatric disorders.

In these experiments, test subjects with maladies ranging from severe brain trauma to bipolar disorder undergo a battery of visual tests. They wear infrared glasses linked to a computer that measures and records subtle eye movements. Similar tests, administered to the participants in an MRI scanner, allow the researchers to monitor brain function associated with eye movement and pinpoint in consistencies. Sweeney says noting parallels in abnormal eye movement and brain activity “gives us an objective way of evaluating patients and treatment response that clinical evaluations, while crucial, can’t provide.” This line of research may also help identify at-risk individuals before the onset of mental illness.

COPYRIGHT 2003 Sussex Publishers, Inc.

COPYRIGHT 2004 Gale Group

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