Effects of particulate bone cements at the bone-implant interface, The

effects of particulate bone cements at the bone-implant interface, The

Wimhurst, J A

We used a rat model in vivo to study the effects of particulate bone cements at the bone-implant

interface. A ceramic pin was implanted into the tibiae of 48 rats. Three types of particle of clinically relevant size were produced from one bone-cement base without radio-opacifier, with zirconium dioxide (ZrO^sub 2^) and with barium sulphate (BaSO^sub 4^). The rats were randomly assigned to four groups to receive one of the three bone cements or normal saline with 2% v/v Sprague-Dawley serum as the control. A total of 10^sup 9^ particles was injected into the knee at 8, 10 and 12 weeks after the original surgery. The animals were killed at 14 weeks and the tibiae processed for histomorphometry. The area of fibrous tissue and the gap between the implant and bone were measured using image analysis.

All three types of particle were associated with a larger area of bone resorption than the control. Only in the case of the BaSO^sub 4^-containing cement did this reach statistical significance (p = 0.01). Particles of bone cement appear to promote osteolysis at the bone-implant interface and this effect is most marked when BaS0^sub 4^ is used as the radiopaque agent.

J Bone Joint Surg [Br] 2001;83-B:588-92.

Received 27 August 1999; Accepted 2 November 1999

One or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. In addition benefits have also been or will he directed to a research fund, foundtion, educational institution, or other non-profit institution with which one or more of the authors is associated.


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J. A. Wimhurst, R. A. Brooks, N. Rushton

From the Orthopaedic Research Unit, University of Cambridge, England

J. A. Wimhurst, FRCS, Specialist Registrar in Orthopaedics

R. A. Brooks, PhD, Research Associate

N. Rushton, MD, FRCS, Director

Orthopaedic Research Unit, University of Cambridge, Addenbrooke’s Hospital, Box 180, Hills Road, Cambridge CB2 2QQ, UK.

Correspondence should be sent to Dr R. A. Brooks.

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