Studies Report Paroxetine Effective in Treatment of PTSD – post traumatic stress disorder
(15th Annual Meeting of the American Psychiatric Association) Data pooled from three 12-week, randomized, double-blind, placebo-controlled trials indicate that paroxetine (Paxil) is well tolerated, and safe and effective in the treatment of post-traumatic stress disorder (PTSD). Primary efficacy measurements for the 428 men and 752 women participating in the study included the Clinician Administered PTSD scale (CAPS-2) and the Global Improvement of the Clinical Global Impression (CGI-I) scale; secondary measurements included CAPS-2 symptom clusters, Davidson Trauma Scale (DTS) and the Sheehan Disability Scale (SDS). Total scores for the CAPS-2 scale decreased significantly (p [less than] 0.001) Secondary measurements produced similar results in favor of paroxetine versus placebo for both genders. However, this finding did not differ in regard to gender on the efficacy instruments. The U.S. Food and Drug Administration is currently reviewing paroxetine for the treatment of PTSD.–C.D. PITTS, R.PH., ET. AL., GlaxoSmithKline, Philadelphia, Pennsylvania.
COPYRIGHT 2001 American Academy of Family Physicians
COPYRIGHT 2001 Gale Group