Peptic ulcer disease and smoking in women

Peptic ulcer disease and smoking in women – Tips from Other Journals

Peptic Ulcer Disease and Smoking in Women Although cigarette smoking is known to be associated with peptic ulcer disease in men, this association has not been studied in women. Anda and colleagues used data from the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study (NHEFS) to evaluate the relationship between smoking and peptic ulcer disease in women.

The NHEFS is based on a subset of data from the National Health and Nutrition Examination Survey (NHANES I), which gathered information from 1971 through 1975 on a representative sample of the U.S. population. NHEFS participants were followed from 1982 through 1984.

The study cohort included 2,851 women who did not report a history of peptic ulcer disease during baseline interviews for the NHANES I study. Of these women, 140 (4.9 percent) developed peptic ulcer disease during the follow-up period. the incidence of peptic ulcer disease in this cohort was 55 cases per 10,000 person-years. The incidence was 1.9 times higher for current smokers as compared with nonsmokers, a difference that persisted after adjustments were made for age, education level, aspirin use, consumption of coffee or tea, and alcohol use.

The risk of peptic ulcer disease was related to the number of cigarettes smoked. Women who smoked less than one pack per day had a relative risk of 1.6, compared with a relative risk of 1.9 for those who smoked more than one pack per day. For former smokers, the probability of developing an ulcer was slightly higher than that for women who had never smoked. During the 12.5 years of follow-up, 10.0 percent of smokers were diagnosed with peptic ulcer disease, compared with 6.4 percent of the former smokers and 5.4 percent of the nonsmokers.

Based on these findings and teh prevalence of smoking among women in the United States, the authors calculate that cigarette smoking may account for 20 percent of the peptic ulcer disease among U.S. women. Data from the NHEFS suggest that reducing the prevalence of cigarette smoking in women will reduce the incidence of peptic ulcer disease in this population. (Archives fo Internal Medicine, July 1990, vol. 150, p.1437.)

COPYRIGHT 1990 American Academy of Family Physicians

COPYRIGHT 2004 Gale Group