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INCOMIN results favor frequent interferon dosage – news – Independent Comparison of Interferon

INCOMIN results favor frequent interferon dosage – news – Independent Comparison of Interferon – Brief Article

Results from the Independent Comparison of Interferon (INCOMIN), a two-year, randomized, multi-center trial conducted in Italy, were published in the April 27, 2002, issue of The Lancet. The INCOMIN trial studied 188 people with relapsing-remitting MS–92 participants were randomly assigned to take Avonex (interferon beta-1a) once a week; 96 were randomly assigned to take Betaseron (interferon beta-1b) every other day.

At the conclusion of the study, 51% of the people who took Betaseron remained relapse-free compared to 36% of those who took Avonex. Trial participants were also given MRIs at the close of the study. The MRIs showed that 55% of those taking Betaseron were free of new brain lesions (or damaged areas), compared with 26% of the people who received Avonex. Those taking Betaseron experienced significantly more adverse injection-site reactions than those using Avonex.

The authors, headed by Dr. Luca Durelli of the University of Torino, suggest that the INCOMIN trial “presents clear evidence that dose frequency and concentration, possibly acting together, can affect disease activity and progression in patients with relapsing-remitting MS.” They went on to say that further studies were needed to see how Avonex might perform if it were given more frequently.

The Society recommends that people consult a qualified health-care professional before making any decisions regarding the disease-modifying drugs.

COPYRIGHT 2002 National Multiple Sclerosis Society

COPYRIGHT 2002 Gale Group