CCR5 and CXCR4 co-receptors in HIV infection

CCR5 and CXCR4 co-receptors in HIV infection

Joseph E. McDade

This article examined the central role played by co-receptor expression and usage in the transmission and pathogenic effects of HIV-1 infection of humans. The review contains a discussion of the HIV-1 phenotypic variants defined by their use of the CCR5 or CXCR4 co-receptors. How the different cellular tropism patterns of these viral variants influence how and where HIV-1 replicates in vivo is also discussed, with emphasis on the thymus and gut-associated lymphoid tissues. The review also contains a consideration of the possible outcomes of the use of co-receptor antagonists as drugs to treat HIV-1 infection in vivo.

Moore JP, Kitchen SG, Pugach P, Zack, JA. The CCR5 and CXCR4 coreceptors–central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retrovimses 2004;20:111-26.

COPYRIGHT 2004 U.S. National Center for Infectious Diseases

COPYRIGHT 2004 Gale Group