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Alternative Medicine Review

Extradigestive manifestation of Helicobacter pylori infection in children and adolescents

Extradigestive manifestation of Helicobacter pylori infection in children and adolescents

P.M. Sherman

Extradigestive manifestation of Helicobacter pylori infection in children and adolescents. Sherman PM, Lin FY. Can J Gastroenterol 2005:19:421-424.

Helicobacter pylori infection fulfills each of Koch’s postulates as a human pathogen causing chronic active gastritis. Disease consequences that develop in a subset of infected subjects include peptic ulcerations, gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. More recently, multiple publications have advocated a role for H pylori infection in causing a variety of extraintestinal manifestations. Many of these reports suffer from being case reports or case series without adequate controls. As a result, purported manifestations may simply be coincidental in nature. On the other hand, increasing evidence supports H pylori infection as a cause of sideropenic (refractory iron deficiency) anemia. Moderate evidence supports H pylori gastric infection as a cause of some cases of immune thrombocytopenic purpura due to molecular mimicry. Guidelines should be adjusted in accordance with advancing knowledge in the field.

COPYRIGHT 2005 Thorne Research Inc.

COPYRIGHT 2005 Gale Group