Acute promyelocytic leukemia (AML-M3) – part 1: Pathophysiology, clinical diagnosis, and differentiation therapy Randolph, Tim R OBJECTIVES: The objectives of this review paper are to: Compare acute leukemia with chronic leukemia and other forms of cancer. Review the pathophysiology and discuss the clinical and diagnostic features of M3. Describe the variant of M3 (M3m or […]
Category: Clinical Laboratory Science
Paroxysmal Nocturnal Hemoglobinuria Smith, Larry J Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal stem cell disorder resulting from a somatic mutation in the hematopoietic stem cell. It is characterized by intravascular hemolysis, cytopenias, frequent infections, bone marrow hypoplasia, and a high incidence of life-threatening venous thrombosis. An absent glycosylphosphatidylinositol (GPI)-anchored receptor prevents several proteins […]
Method comparison studies for prostate specific antigen and unconjugated estriol immunoassays Koenn, Mary E OBJECTIVE: Method comparison studies were performed in order to move a semi-automated prostate specific antigen (PSA) immunoassay and a manual unconjugated estriol (uE^sub 3^) immunoassay to an automated chemistry immunoassay analyzer. The results of the two method comparison studies are compared. […]
Modifying blood bank processes for efficiency and effectiveness: A case study Butch, Suzanne H There is no single method or process that works effectively in every transfusion service. Since change is complicated by personnel, financial, and regulatory issues, the decision to retain or modify current processes should be undertaken with sufficient data to support the […]
Growth Inhibition of Human Colon Cancer Cells by Plant Compounds Duessel, Sharon OBJECTIVE: Evidence is accumulating that compounds of plant origin (phytochemicals) exert anti-cancer effects. The purpose of this study was to determine if resveratrol, cinnamaldehyde, and piperine (from red grapes, cinnamon, black pepper respectively) have anti-proliferative effects on colon cancer. DESIGN: Quantitative effects of […]
A Swollen Eye? A Case of Rapidly Progressive Neuroblastoma Spence, Libby An eight-month-old female was seen by her physician due to irritability and sleeplessness of several nights duration. No physical reason was detected for her discomfort. Two weeks later she returned with a swollen left eye. A CBC revealed a 14,600 WBC and low-grade anemia. […]
Government 103: What Happened to the Great Idea? Griffith, James T ABBREVIATIONS: HIPAA = Health Insurance Portability and Accountability Act; HR = House of Representatives; PL = public law; WEDI = Workgroup for Electronic Data Exchange INDEX TERMS: Federal governments; law; legislative action. Clin Lab Sci 2006;19(1):54 The great idea is the great foundation of […]
Image Atlas Series/inQUIZator Series Griffith, James T Indiana Pathology Images; 2004, 2005 http://www.ipimages.com INDEX TERMS: clinical microbiology; electronic images; learning tools; review. Each of the following five CD-ROMs is described to be for the express use of: educators (PowerPoint lectures, color images for examinations, student laboratory manuals, intranet website postings); undergraduate, graduate, and medical students, […]
Membranoproliferative Glomerulonephritis Type II in a 10-year-old Girl Tibbs, Martha E The clinical course of a 10-year-old female patient who presented with hematuria, proteinuria, and hypertension is described. Four months after being diagnosed with acute glomerulonephritis, the child was referred to a pediatric nephrologist due to persistent hematuria and unresolved proteinuria. A renal biopsy was […]
ASCLS 2001 legislative initiatives Hansen, Kathy WASHINGTON BEAT The 107th Congress has completed its organizational activities and is now preparing to deal with substantive legislative issues. On the healthcare agenda, the focus will be: Medicare Structural Reform; Prescription Drug Benefits; Patients Bill of Rights; and potentially some additional Medicare reimbursement issues. ASCLS again will work […]