Study finds results from CompuMed’s OsteoGram bone density test comparable to results from expensive bone densitometry machines

Study finds results from CompuMed’s OsteoGram bone density test comparable to results from expensive bone densitometry machines – Report published in current issue of Journal of Bone and Mineral Research

MANHATTAN BEACH, Calif.–(BUSINESS WIRE)–Nov. 17, 1994– CompuMed Inc. (Nasdaq Small Cap:CMPD) today announced the publication of an article in the current issue of the Journal of Bone and Mineral Research (vol. 9, No. 11, pgs. 1745-1749). The article presents the results of a major clinical study that compared bone density readings obtained from CompuMed’s OsteoGram, which uses computer analysis of simple hand x-rays, to readings obtained from bone density measurement techniques requiring expensive hospital-based equipment. Senior author of the article was Michael Kleerekoper, M.D., Director of Bone and Mineral Metabolism and Gerontology Research, Dept. of Internal Medicine, at Wayne State University School of Medicine in Detroit, Mich. The study was conducted by Dr. Kleerekoper and a team of researchers from Wayne State University and Henry Ford Health Sciences Center, also in Detroit, Mich.

Until recently, bone density was determined by either dual-energy x-ray absorptiometry (DXA), which is the direct measurement of the hip and spine using dedicated bone densitometry machines, or quantitative computed tomography (QCT), which is the direct measurement of the spine using specially equipped CAT scanner machines. Although osteoporosis is recognized as a significant community health problem, the considerable expense and complexity of these diagnostic machines has made them inaccessible to many U.S. residents. The OsteoGram is significantly less expensive and complex because it uses computer analysis of simple hand x-rays taken on existing and widely available standard x-ray equipment to measure bone density.

“As long as bone density measurement tools are not widely deployed, most osteoporosis will remain undiagnosed and untreated until the latter stages of the disease, which is often after osteoporotic fractures have already occurred,” said Kleerekoper. “This study shows, however, that radiographic absorptiometry (RA) is as reliable as the more expensive and complex techniques. As a result, this easy-to-use test has the potential to make reliable, inexpensive bone mass measurements widely available to all people.”

In the article, titled “Comparison of Radiographic Absorptiometry with Dual-Energy X-ray Absorptiometry and Quantitative Computed Tomography in Normal Older White and Black Women,” Dr. Kleerekoper and his colleagues discuss how they measured bone mineral density (BMD) of the phalanges of the hand in 199 older, postmenopausal women using the RA technique of the OsteoGram. These women were determined previously to have normal bone mineral density through DXA and QCT measurements. After recording the BMD readings for the women, the researchers developed a correlation matrix to compare the data with readings from the DXA and QCT techniques. Based on this matrix, they concluded that, in general, RA was related to the various DXA and QCT measurement sites as well as these sites were related to each other and that RA is an acceptable measure of phalangeal BMD.

“The processing power of today’s PC chips combined with our unique OsteoGram software had made computerized x-ray image analysis a powerful tool for measuring bone density,” said Rod N. Raynovich, president and chief executive officer of CompuMed. “This major study confirms that this simple, effective, and inexpensive technology can assist physicians in determining patient risk for osteoporosis.”

Osteoporosis is the most common metabolic bone disorder, characterized by the loss of bone, reduced bone strength, and increased risk of bone fractures. Often, osteoporosis makes the body’s bones so weak, they break with only the slightest force. There are 25 million people in the United States and more than 200 million people in the developed nations of the world that suffer from this crippling, costly, and frequently fatal disease. According to the National Osteoporosis Foundation, half of all women and a fifth of all men currently in the United States will eventually break bones, mostly of the spine, hip, and wrist, because of osteoporosis.

CompuMed, based in Manhattan Beach, Calif., is focused on providing solutions to important medical problems through the use of computer technology. In addition to the OsteoGram, the company has business units focusing on telemedicine for cardiology, which provides on-line computer interpretation of electrocardiograms (ECGs) to about 1,600 doctors and healthcare facilities in the United States, and Detoxahol, a substance and delivery technology it is developing to facilitate the rapid reduction of blood alcohol levels in people who have been drinking.

CONTACT: CompuMed Inc.

Rod N. Raynovich, 310/643-5106 ext. 299


Noonan/Russo Communications Inc.


Anthony J. Russo ext. 202

Rich Tammero ext. 222

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